Key takeaways: Naproxen, a non-steroidal anti-inflammatory drug (NSAID), and hydrocodone, an opioid, work differently. But they’re both options for treating moderate-to-severe pain. Naproxen is available over-the-counter and with a prescription, whereas hydrocodone is a controlled, prescription-only medication. Naproxen sodium, which doctors classify as an NSAID, can treat and relieve head pain. diclofenac (Cataflam) Doctors will determine the specific dosage for each medication when they provide the The absorption of diclofenac potassium to patient’s blood stream is faster than diclofenac sodium.7 As a rule, the earlier the analgesic absorbed the quicker the onset of action will be. So, diclofenac potassium is a fast acting analgesic and useful for the patients who are required immediate relief from inflammatory pain.12 Naproxen lasts longer than ibuprofen. The half-life of ibuprofen is two to four hours, while naproxen is 12 to 17 hours. (Half-life is when half the original dose is still circulating in your bloodstream.) In layman’s terms, you take ibuprofen once every four to six hours, while naproxen is only repeated once every eight to 12 hours. Signs of an allergic reaction include skin reddening, blisters, and a rash. Avoid other medications containing acetaminophen when using Tylenol. You should also not take the medication for longer than 10 days for pain relief or three days for fever relief. Don’t take more than 3 g of acetaminophen per day (maximum recommended daily dose). bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; heart problems - swelling, rapid weight gain, feeling short of breath; kidney problems - fever, rash, nausea, loss of appetite, joint pain, urinating less than usual, blood in your urine, weight gain; Ratings & Reviews Diclofenac has an average rating of 7.4 out of 10 from a total of 687 ratings on Drugs.com. 69% of reviewers reported a positive effect, while 20% reported a negative effect. Celebrex (celecoxib) and naproxen are nonsteroidal anti-inflammatory drugs ( NSAIDs) used for the relief of pain, fever, swelling, and tenderness caused by arthritis, acute pain, and menstrual cramps. Brand names for naproxen include Aleve, Naproxen, EC-Naproxen and Anaprox/Anaprox DS. Etodolac. Twenty-nine RCTs were included. Studies compared etodolac with either placebo or non-selective NSAIDs. Compared with non-selective NSAIDs (naproxen, piroxicam, diclofenac, indomethacin, tenoxicam, ibuprofen, nabumetone or nimesulide), etodolac (600–1000 mg/day) was equally efficacious and of equivalent or superior gastrointestinal (GI) tolerability. • Diclofenac has more selectivity for COX-2 than naproxen. • Diclofenac appears to inhibit the lipoxygenase pathways, reducing inflammation by decreasing production of leukotrienes. • Diclofenac also inhibits arachidonic acid release and stimulates its reuptake QwVm.